“Multi-Scale Simulations To Uncover Flow And Transport Behavior In A Physiologically-Realistic Lung” by Jessica Oakes, University of California, Berkeley

Abstract

Pulmonary diseases cause substantial medical and financial burdens worldwide and are typically caused by inhalation of air pollution or cigarette smoke.  The coupling of multi-physics simulations with animal or human experimental data is necessary to validate model predictions.  While recent advances in computational resources have enabled sophisticated simulations of airflow and particle transport in the pulmonary airways, it is infeasible to resolve the physics for all scales of the lung. To address this challenge, the computational domain may be split, where lower-dimensional models of the small airways may be connected to large airway 3D models.  In this seminar, experimentally parameterized 3D-0D and 3D-1D finite element simulations of airflow and particle transport will be introduced.   Regional and local deposition throughout the respiration cycle will be highlighted.  Future directions in therapeutic delivery optimization in asthmatic and emphysematous patients and the potential health consequences to electronic cigarette exposure aerosol will be discussed.

 Biosketch:

Jessica is a UC Presidential Postdoctoral Scholar at UC Berkeley.  Following the completion of her PhD in 2013, Jessica traveled to Paris, France for a one-year postdoctoral appointment at INRIA.  The NSF, the Burroughs Wellcome Fund, a Whitaker Scholarship, and an INRIA Postdoctoral Grant have supported her work.  Recently, Jessica was awarded an American Lung Association Grant to investigate the health effects of e-cigarettes.   Jessica grew up in Western New York and enjoys hiking, reading, art, and traveling.  More information may be found at www.jessicamoakes.com.

Date/Time:
Date(s) - Apr 19, 2017
4:00 pm - 5:00 pm

Location:
38-138 Engineering IV
420 Westwood Plaza Los Angeles CA 90095